2023 iwCLL Program Agenda

**AGENDA topics and times subject to change** As of 04/20/23

Friday, October 6

7:30 AM

YIM Continental Breakfast

8:00 AM

Young Investigator Meeting

6:00 PM

iwCLL Welcome Reception

Saturday, October 7, 2023

7:15 AM

Continental Breakfast

8:15 AM

Welcome and Introductions

Jennifer Brown, MD, PhD

8:30 AM

Honoring the Past: In Memoriam and 20 Years of iwCLL

Session 1: Integrative Aspects of Genomics

Session Co-Chair: Christopher Oakes, MD, PhD

8:40 AM

Multiomic Integration in CLL

Cynthia K. Hahn, MD

8:55 AM

Whole-Genome Analysis of CLL and Interplay of Coding, Non-Coding, Transcriptome and Epigenetic Events

Pauline Robbe, PhD

9:10 AM

Genomics of Richter’s Transformation: Part I

Ferran Nadeu, PhD

9:20 AM

Genomics of Richter’s Transformation: Part II

Erin Parry, MD, PhD

9:30 AM

Commentary and Consensus Regarding the Genomics of Richter’s Transformation

Ferran Nadeu, PhD and Erin Parry, PhD

9:40 AM

Panel Discussion With Interactivity and Audience Q&A

9:50 AM

Oral and Poster Abstracts

10:10 AM

Morning Break

Session 2: Proteomics and Metabolism of CLL

Session Co-Chair: Catherine Wu, MD

10:35 AM

Proteogenomic Characterization of CLL and Drug Response/Resistance

Sascha Dietrich, MD

10:50 AM

CLL Proteomics and Immunoproteomics

Catherine Wu, MD

11:05 AM

Cancer Metabolism

TBD

11:20 AM

Panel Discussion With Interactivity and Audience Q&A

11:35 AM

Oral and Poster Abstracts

12:05 PM

Lunch

12:55 PM

Industry Supported Symposium

Session 3: Microenvironment and Pre-Clinical Immunotherapies

Session Co-Chair: Adrian Wiestner, MD, PhD

1:55 PM

Anti-Tumor Immunity in the Lymphoid Microenvironment

Martina Seiffert, PhD

2:10 PM

The Tumor Supportive Microenvironment of CLL

Jerome Paggetti, PhD

2:25 PM

Modeling the Tumor Microenvironment of CLL

Christina Scielzo, PhD

2:35 PM

The Tumor Microenvironment and Genetic Heterogeneity of CLL

Clare Sun, MD

2:45 PM

Panel Discussion With Interactivity and Audience Q&A

3:05 PM

Oral and Poster Abstracts

3:25 PM

Afternoon Break

3:50 PM

Keynote

Session 4: Debate and Roundtable – How Do We Define Success in CLL?

Session Co-Chair: John Seymour, MBBS, PhD

4:20 PM

Multiparty “Statement of Perspective”

Michele Nadeem Baker
Danielle Brander, MD
Barbara Eichhorst, MD
Carsten Niemann, MD, PhD
Andrew Roberts, PhD
William Wierda, MD, PhD

4:55 PM

Panel Discussion With Interactivity and Audience Q&A

5:30 PM

Oral and Poster Abstracts

5:50 PM

Adjourn

End of Day 1

Sunday, October 8

7:00 AM

Industry Supported Symposium

7:15 AM

Continental Breakfast

Session 5: Optimizing Initial Therapy of CLL

Session Co-Chair: Matthew Davids, MD, MMSc

8:15 AM

The Role Today of Continuous BTK Inhibitors

Kerry Rogers, MD

8:30 AM

Updated Perspective on Time-Limited Venetoclax + Obintuzumab

Othman Al-Sawaf, MD

8:45 AM

Current and Future Use of BTKi + BCL-2i Combinations

Nitin Jain, MD

9:00 AM

Panel Discussion With Interactivity and Audience Q&A

9:15 AM

Trials in Progress

9:35 AM

Oral and Poster Abstracts

9:55 AM

Morning Break

10:20 AM

Industry Supported Symposium

Session 6: Mechanisms of Resistance

Session Co-Chair: Jennifer Woyach, MD

11:20 AM

Resistance to Covalent BTKi

Adrien Wiestner, MD, PhD

11:35 AM

Resistance to Non-Covalent BTKi

Varsha Gandhi, MD

11:50 AM

Resistance to BCL2i

Rachel Thijssen, Phd

12:05 PM

Panel Discussion With Interactivity and Audience Q&A

12:20 PM

Oral and Poster Abstracts

12:40 PM

Lunch

1:30 PM

Industry Supported Symposium

Session 7: Future Directions for the Treatment of Relapsed/Refractory CLL

Session Co-Chair: Arnon Kater, MD, PhD

2:30 PM

BTK Degraders – From Bench To Bedside

Alexey Danilov, MD, PhD

2:40 PM

Novel Inducers of Apoptosis

Deepa Sampath, PhD

2:50 PM

How to Overcome T-Cell Dysfunction: Bispecifics

Arnon Kater, MD, PhD

3:00 PM

How to Overcome T-Cell Dysfunction: Cellular Therapies

Jos Melenhorst, PhD

3:10 PM

Panel Discussion with Interactivity and Audience Q&A

3:25 PM

Trials in Progress

3:45 PM

Oral and Poster Abstracts

4:05 PM

Binet/Rai Medal Presentation

4:15 PM

Adjourn
Wine & Cheese Poster Session and Reception

End of Day 2

Monday, October 9

7:00 AM

Industry Supported Symposium

7:15 AM

Continental Breakfast

Session 8: Richter’s Transformation – From Biology to Clinic

Session Co-Chair: Inhye Ahn, MD

8:15 AM

In Vivo Modeling of CLL Transformation

Silvia Deaglio, MD, PhD

8:25 AM

In Vivo Modeling of CLL Transformation: Multiplex In Vivo CRISPR Editing

Elisa Ten Hacken, PhD

8:35 AM

In Vivo Modeling of CLL Transformation: TP53 and CDKN2a/b Model

Dimitar Efremov, MD, PhD

8:45 AM

Panel Discussion on In Vivo Modeling

8:55 AM

Chemoimmunotherapy and BCR-Targeted Agents for Richter’s Transformation

Sameer Parikh, MBBS

9:05 AM

Investigational Therapies for Richter’s Transformation: Bispecifics

Philip Thompson, BA, BSW, MSW, PhD

9:15 AM

Investigational Therapies for Richter’s Transformation: Cellular Therapies

Tanya Siddiqi, MD

9:25 AM

Panel Discussion with Interactivity and Audience Q&A

9:35 AM

Oral and Poster Abstracts

9:55 AM

Morning Break

Session 9: Immunodeficiency and Infections in Patients with CLL

Session Co-Chair: Carsten Niemann, MD, PhD

10:20 AM

CLL Vaccine Responsiveness

Chris Pleyer, MD

10:35 AM

What Can We Learn from COVID About Immune Dysfunction and Risk of Infections in CLL?

Yair Herishanu, MD

10:50 AM

General Management of CLL patients from a Vaccine and Prophylaxis Standpoint

Carolyn Owen

11:05 AM

Panel Discussion with Interactivity and Audience Q&A

11:20 AM

Oral and Poster Abstracts

11:40 AM

Industry Supported Symposium

12:40 PM

LUNCH

Session 10: Global Perspective on CLL Management – Real World Data and Patient Experiences

Session Co-Chair: Anna Schuh, MD, PhD

1:30 PM

The Impact of the War on Management of Patients with CLL in Ukraine: What can the iwCLL do to Mitigate Impact in Short and Longer Term

Iryna Kryachok,, Prof., PhD

1:40 PM

Managing Patients with CLL from Different Socio-Economic Backgrounds in Argentina

Miguel Pavlovsky, MD

1:50PM

Update on the iwCLL Capacity Building Pilot Program in Tanzania

William Frank Mawalla, MD

2:00 PM

Challenges of Diagnosis and Management of Patients with CLL in South Korea

Ja Min Byun, MD, PhD

2:10 PM

Trial Updates from China

Shenmiao Yang, MD

2:20 PM

Global Survey Results from the CLL Advocates Network

Nick York

2:30 PM

Panel Discussion With Interactivity and Audience Q&A

2:50 PM

Afternoon Break

Session 11: Past, Present, and Future of CLL

Session Co-Chair: Jennifer R. Brown, MD, PhD

3:15 PM

TBD

3:30 PM

Remaining Unmet Needs in the Care of CLL

TBD

3:45 PM

Role of the iwCLL Going Forward

TBD

4:00 PM

Panel Discussion With Interactivity and Audience Q&A

4:20 PM

Closing Comments/iwCLL 2023 Awards/2025 Announcement

Jennifer R. Brown, MD, PhD

4:35 PM

Close of Workshop